Brain Disease

//Brain Disease
Brain Disease2018-07-18T11:24:52+00:00

Disorders affecting the brain are among the most costly to society because they can last for years to a lifetime. Work has focused on autism and Alzheimer disease and the potential role of environmental agents in causing these conditions.

Selected papers

Nataf, R., Skorupka, C., Amet, L., Springbett, A. and Lathe, R. (2006) Porphyrinuria in autistic disorder; implications for environmental toxicity. Toxicol. App. Pharmacol. 214, 99-108.

Lathe, R. (2006) Autism, Brain and Environment. Jessica Kingsley Publishers, London and Philadelphia

Lathe, R. (2009) Fragile X and autism. Autism 13, 194-197

Lathe, R. and Harris, A. (2009) Differential display detects host nucleic acid motifs altered in scrapie-infected brain. J Mol Biol. 392, 813-822

Lathe, R., Sapronova, A. and Kotelevtsev, Y. (2015) Atherosclerosis and Alzheimer – diseases with a common cause? Inflammation, oxysterols, vasculature. BMC Geriatr. 14, 36

Itzhaki, R.F., Lathe, R., Balin, B.J., Ball, M.J., Bearer, E.L., Braak, H., Bullido, M.J., Carter, C., Clerici, M., Cosby, S.L., Del Tredici, K., Field, H., Fulop, T., Grassi, C., Griffin, W.S., Haas, J., Hudson, A.P., Kamer, A.R., Kell, D.B., Licastro, F., Letenneur, L., Lövheim, H., Mancuso, R., Miklossy, J., Otth, C., Palamara, A.T., Perry, G., Preston, C., Pretorius, E., Strandberg, T., Tabet, N., Taylor-Robinson, S.D. and Whittum-Hudson, J.A. (2016) Microbes and Alzheimer’s Disease. J Alzheimers Dis. 51, 979-984

Lathe, R. and Haas, J.G. (2017) Distribution of cellular HSV-1 receptor expression in human brain. J. Neurovirol. Epub ahead of print

The prion protein PRNP has been centrally implicated in the transmissible spongiform encephalopathies (TSEs), but its normal physiological role remains obscure.We highlight emerging evidence that PRNP displays antimicrobial activity, inhibiting the replication of multiple viruses, and also interacts directly with Alzheimer’s disease (AD) amyloid-(A) peptide whose own antimicrobial role is now increasingly secure.

Selected papers

Prion Protein PRNP: A New Player in Innate Immunity? The Aβ Connection. Journal of Alzheimer’s Disease Reports 1 (2017) 263–275. Richard Lathea,b,* and Jean-Luc Darlixc,*
aDivision of Infection and Pathway Medicine, University of Edinburgh, Edinburgh, UK
bShemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences,
Pushchino, Moscow Region, Russia
cFaculté de Pharmacie, Centre Nationale de la Recherche Scientifique (CNRS) Unité 7213, Université de Strasbourg, Illkirch, France