Recent Publications (2001 onwards)

Lathe, R. (2001) Hormones and the hippocampus. J. Endocrinol. 169, 205-231.

Rose, K., Allan, A., Gauldie, S., Stapleton, G., Dobbie, L., Dott, K., Martin, C., Wang, L., Hedlund, E., Seckl, J.R., Gustafsson, J.A. and Lathe, R. (2001). Neurosteroid Hydroxylase CYP7B: Vivid Reporter Activity in Dentate Gyrus of Gene-Targeted Mice and Abolition of a Widespread Pathway of Steroid and Oxysterol Hydroxylation. J. Biol. Chem. 276, 23937-23944.

Bean, R., Seckl, J.R., Lathe, R. and Martin, C. (2001) Ontogeny of the neurosteroid enzyme CYP7B in the mouse. Molec. Cell. Endocrinology 174, 137-144.

Davies, B., Kearns, I., Ure, J., Davies, C. and Lathe, R. (2001). Loss of Hippocampal Serine Protease BSP1/Neuropsin Predisposes to Global Seizure Activity. J. Neuroscience 21, 6993-7000.

Opsahl, M.L., McClenaghan, M., Springbett, A., Lathe, R., Colman, A. and Whitelaw, C.B.A. (2002) Multiple effects of genetic background on variegated transgene expression in mice. Genetics, 160, 1107-1112.

Lathe, R., and Seckl, J.R. (2002). Neurosteroids and brain sterols. In: Mason, J.I. (ed.) Genetics of Steroid Biosynthesis and Function. Modern Genetics, volume 6, Harwood Academic, Amsterdam. pp 405-472.

Vico, P., Cauet, G., Rose, R., Lathe, R. and E. Degryse. (2002) Dehydroepiandrosterone (DHEA) metabolism in Saccharomyces cerevisiae expressing mammalian steroid hydroxylase CYP7B: Ayr1p and Fox2p display 17beta-hydroxysteroid dehydrogenase activity. Yeast 19, 873-886.

Rose, K., Mason, J.O. and Lathe, R. (2002) Hybridization parameters revisited: solutions containing SDS. Biotechniques 33, 54-58.

Zhang Weihua, Z., Lathe, R., Warner, M. and Gustafsson, J.A. (2002) An endocrine pathway in the prostate, ERbeta, AR, 5alpha-androstane-3beta,17beta-diol, and CYP7B1, regulates prostate growth. Proc. Natl. Acad. Sci. USA 99, 13589-13594.

Lathe, R. (2002) Steroid and sterol 7-hydroxylation: Ancient pathways. Steroids 67, 967-77.

Lauer, P., Metzner, H.J., Zettlmeissl, G., Li, M., Smith, A.G., Lathe, R. and Dickneite, G. (2003) Targeted inactivation of the mouse locus encoding coagulation factor XIII-A: hemostatic abnormalities in mutant mice and characterization of the coagulation deficit. Thromb. Haemost. 2002; 88: 967-974.

Lathe, R. and Le Page, M. (2003) Toxic metal clue to autism. New Scientist, 18 June.

Lathe, R. (2003) See the bigger picture. Autism File Issue 14, 19-22.

Yau, J.L.W., Rasmuson, S., Andrew, R., Graham, M., Noble, J., Olsson, T., Fuchs, E., Lathe, R. and Seckl, J.R. (2003) DHEA 7-hydroxylase CYP7B: Enrichment in primate hippocampus and functional depletion in Alzheimer’s disease. Neuroscience 121, 307–314.

Opsahl, M.L., Springbett, A., Lathe, R., Colman, A., McClenaghan, M. and Whitelaw, C.B. (2003) Mono-allelic expression of variegating transgene locus in the mouse. Transgenic Res. 12, 661-669.

Rae, M.T., Niven, D., Ross, A., Forster, T., Ghazal, P., Lathe, R., Critchley, H.O.D. and Hillier, S.G. (2004) Signalling at the human ovarian surface: steroid-signature and response to interleukin-1alpha addressed by microarray analysis. J. Endocrinol., 183, 19-28.

Lathe, R. (2004) Fast tidal cycling and the origin of life. Icarus 168, 18-22.

Lathe, R. (2004) The individuality of mice. Genes Brain & Behavior 3, 317-327.

Omoto, Y., Lathe, R., Warner, M. and Gustafsson, J.A. (2005) Early onset of puberty and early ovarian failure in CYP7B1 knockout mice. Proc. Natl. Acad. Sci. USA 102, 2814-2819.

Wilson, K.E. et al. (2005) Comparative proteomic analysis using samples obtained with laser microdissection and saturation dye labelling. Proteomics 5, 3851-3858.

Lathe, R. (2005) Tidal chain reaction and the origin of replicating biopolymers. Intl. J. Astrobiol. 4, 19-31.

Lathe, R (2006) Early tides – response to Varga et al. Icarus 80, 277-280.

Lathe, R. (2006) Autism, Brain and Environment. Jessica Kingsley Publishers, London and Philadelphia. (Link) (Reviews).

Lathe, R. and Prave, T. (2006) Astrobiology – Biochemistry at a distance. The Biochemist 28 (2), 29-32.

Nataf, R., Skorupka, C., Amet, L., Springbett, A. and Lathe, R. (2006) Porphyrinuria in autistic disorder; implications for environmental toxicity. Toxicol. App. Pharmacol. 214, 99-108.

Lathe, R. (2006) Autism and the link between brain and body. ASA Autism Advocate Online, Special Issue, December.

Lathe, R. (2008) Environmental factors and limbic vulnerability in childhood autism. Am. J. Biochem. Biotech. 4, 183-197.

Nataf, R., Skorupka, C., Lam, A., Springbett, A. and Lathe, R. (2008) Porphyrinuria in childhood autistic disorder is not associated with urinary creatinine deficiency. Pediatr Int. 50, 528-532.

Lathe, R. (2009) Fragile X and autism. Autism 13, 194-197.

Sugiyama, N., Andersson, S., Lathe, R., Fan, X., Alonso-Magdalena, P., Schwend, T., Nalvarte, I., Warner, M., Gustafsson, J.A. (2009) Spatiotemporal dynamics of the expression of estrogen receptors in the postnatal mouse brain. Mol. Psychiatry 14, 223-232.

Lathe, R. (2009) Microwave electromagnetic radiation and autism. EJAP 5, 11-30.

Lathe, R. and Harris, A. (2009) Differential display detects host nucleic acid motifs altered in scrapie-infected brain. J Mol Biol. 392, 813-822

St Clair, J., Campbell-Palmer, R. and Lathe R. (2014) Sex ratios provide evidence for monozygotic twinning in the ring-tailed lemur, Lemur catta. Twin Res Hum Genet. 17, 51-55

Lathe, R. and Kotelevtsev, Y. (2014) Steroid signaling: ligand-binding promiscuity, molecular symmetry, and the need for gating. Steroids 82, 14-22

Lathe, R., Sapronova, A. and Kotelevtsev, Y. (2015) Atherosclerosis and Alzheimer – diseases with a common cause? Inflammation, oxysterols, vasculature. BMC Geriatr. 14, 36 (2015)

Lathe, R., Kotelevtsev, Y. and Mason, J.I. (2015) Steroid promiscuity: diversity of enzyme action. J Steroid Biochem Mol Biol. 151, 1-2

Laman, A.G., Lathe, R., Savinov, G.V., Shepelyakovskaya, A.O., Boziev, Kh.M., Baidakova, L.K., Chulin, A.N., Brovko, F.A., Svirshchevskaya, E.V., Kotelevtsev, Y., Eliseeva, I.A., Guryanov, S.G., Lyabin, D.N., Ovchinnikov, L.P. and Ivanov, V.T. (2015) Innate immunity: bacterial cell-wall muramyl peptide targets the conserved transcription factor YB-1. FEBS Lett. 589, 1819-1824

Itzhaki, R.F., Lathe, R., Balin, B.J., Ball, M.J., Bearer, E.L., Braak, H., Bullido, M.J., Carter, C., Clerici, M., Cosby, S.L., Del Tredici, K., Field, H., Fulop, T., Grassi, C., Griffin, W.S., Haas, J., Hudson, A.P., Kamer, A.R., Kell, D.B., Licastro, F., Letenneur, L., Lövheim, H., Mancuso, R., Miklossy, J., Otth, C., Palamara, A.T., Perry, G., Preston, C., Pretorius, E., Strandberg, T., Tabet, N., Taylor-Robinson, S.D. and Whittum-Hudson, J.A. (2016) Microbes and Alzheimer’s Disease. J Alzheimers Dis. 51, 979-984

Laman, A.G., Lathe, R., Shepelyakovskaya, A.O., Gartseva, A., Brovko, F.A., Guryanova, S., Alekseeva, L., Meshcheryakova, E.A. and Ivanov, V.T. (2016) Muramyl peptides activate innate immunity conjointly via YB1 and NOD2. Innate Immunity. Published online September 30

Lathe, R. The chemosensory brain requires a distributed cellular mechanism to harness information and resolve conflicts – is consciousness the forum? (2016) Commentary on Morsella et al. Behavioral and Brain Sciences, in press