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| PDF files |
| Note: files for educational use only; copyright of publisher - printing/distribution will require specific permission. Commercial use prohibited. |
| Stapleton, G., Steel, M., Richardson, M., Mason, J.O., Rose, K.A., Morris, R.G.M. and Lathe, R. (1995). A novel cytochrome P450 expressed primarily in brain. J. Biol. Chem. 270, 29739-29745. (pdf) |
| Lathe,
R. (1996). Mice, gene targeting and behaviour; more than just genetic
background. Trends Neurosci. 19, 183-186. (pdf) |
| Rose,
K.A., Stapleton, G., Dott, K., Kieny, M.P., Best, R., Schwarz, M.,
Russell, D.W., Björkhem, Seckl, J. and Lathe, R. (1997). Cyp7b, a
novel brain cytochrome P450, catalyzes the synthesis of neurosteroids
7alpha-hydroxy dehydroepiandrosterone and 7alpha-hydroxy pregnenolone.
Proc. Natl. Acad. Sci. USA 94, 4925-4930. (pdf) |
| Dobie
K, Mehtali M, McClenaghan M, Lathe R. (1997) Variegated gene expression
in mice. Trends Genet. 13, 127-130. (pdf) |
| Steel, M., Moss, J., Clark, K.A., Kearns, I.R., Davies, C., Morris, R.G.M., Skarnes, W.C. and Lathe, R. (1998). Gene-trapping to identify and analyze genes expressed in the mouse hippocampus.Hippocampus 8, 444-457. (pdf) |
| Davies,
B.J., Pickard, B.S., Steel, M. and Morris, R.G.M. and Lathe, R. (1998)
Serine proteases in rodent hippocampus. J. Biol. Chem. 273,
23004–23011. (pdf) |
| Setchell, K.D.R., Schwarz, M., Lund, E.G., Davis, D.L., Lathe, R., Sokol, R.J. and Russell, D.W. (1998). Identification of a new inborn error in bile acid synthesis: mutation of the oxysterol 7alpha-hydroxylase gene causes severe neonatal liver disease. J. Clin. Invest. 102, 1690-1703. (pdf) |
| Pickard, B.S., Davies, B.J., Rose, K.A., Stapleton, G., Steel, M. and Lathe, R. (1999). Brain region-specific genes: the hippocampus. In Crusio, W.E. and Gerlai, R. (eds.) Handbook of Molecular Genetic Techniques for Brain and Behaviour Research, Elsevier, pp 212-224. (pdf) |
| Lathe,
R. (2001) Hormones and the hippocampus. J. Endocrinol. 169,
205-231. (pdf) |
| Rose,
K., Allan, A., Gauldie, S., Stapleton, G., Dobbie, L., Dott, K., Martin,
C., Wang, L., Hedlund, E., Seckl, J.R., Gustafsson, J.A. and Lathe,
R. (2001). Neurosteroid Hydroxylase CYP7B: Vivid Reporter Activity
in Dentate Gyrus of Gene-Targeted Mice and Abolition of a Widespread
Pathway of Steroid and Oxysterol Hydroxylation. J. Biol. Chem.
276, 23937-23944. (pdf) |
| Davies, B., Kearns, I., Ure, J., Davies, C. and Lathe, R. (2001). Loss of hippocampal serine protease BSP1/Neuropsin predisposes to global seizure activity. J. Neuroscience 21, 6993-7000. (pdf) |
| Lathe,
R., and Seckl, J.R. (2002). Neurosteroids and brain sterols. In: Mason,
J.I. (ed.) Genetics of Steroid Biosynthesis and Function. Modern
Genetics, volume 6, Harwood Academic, pp 405-472. (pdf) |
| Lathe,
R. (2002). Steroid and sterol 7-hydroxylation: Ancient pathways. Steroids
67, 967-977. (pdf) |
| Weihua Z, Lathe R, Warner M, Gustafsson JA. (2002) An endocrine pathway in the prostate, ERbeta, AR, 5alpha-androstane-3beta,17beta-diol, and CYP7B1, regulates prostate growth. Proc. Natl. Acad. Sci. USA. 99, 13589-13594. (pdf) |
| Yau,
J.L.W., Rasmuson, S., Andrew, R., Graham, M., Noble, J., Olsson, T.,
Fuchs, E., Lathe, R. and Seckl, J.R. (2003). DHEA 7-hydroxylase CYP7B:
Enrichment in primate hippocampus and functional depletion in Alzheimer’s
disease. Neuroscience 121, 307-314. (pdf) |
| Lathe, R. (2004) Fast tidal cycling and the origin of life. Icarus 168, 18-22. (pdf) |
| Lathe, R (2004) The individuality of mice. Genes Brain Behav. 3, 317-327. (pdf) |
| Omoto, Y., Lathe, R., Warner, M. and Gustafsson, J.A. (2005) Early onset of puberty and early ovarian failure in CYP7B1 knockout mice. Proc. Natl. Acad. Sci. USA 102, 2814-2819. (pdf) |
| Lathe, R. (2005) Tidal chain reaction and the origin of replicating biopolymers. Intl. J. Astrobiol. 4, 19-31. (pdf) |
| Lathe, R (2006) Early tides - response to Varga et al. Icarus 80, 277-280. (pdf) |
| Nataf, R., Skorupka, C., Amet, L., Springbett, A. and Lathe, R. (2006) Porphyrinuria in autistic disorder; implications for environmental toxicity. Toxicol. App. Pharmacol. 214, 99-108. (pdf) |
| Lathe, R. (2006) Autism and the link between brain and body. ASA Autism Advocate Online, Special Issue, December. (pdf) |
Nataf R, Skorupka C, Lam A, Springbett A, Lathe R. (2008) Porphyrinuria in childhood autistic disorder is not associated with urinary creatinine deficiency. Pediatr Int. 2008 50, 528-532. pdf |
| Lathe, R. (2008) Environmental factors and limbic vulnerability in childhood autism. Am. J. Biochem. Biotech. 4, 183-197. (pdf) |
| Lathe, R (2009). Microwave electromagnetic rediation and autism. EJAP 5, 11-30. (pdf) |